Morphology of Marburg Virus NP–RNA

Etymologia: Marburg Virus

Forty years of marburg virus.

Forty years ago, in early August 1967, the first filovirus ever detected, Marburg virus, made its appearance in Europe, causing severe and often fatal hemorrhagic fever in laboratory workers in Marburg and Frankfurt and, about 4 weeks later, in Belgrade. The etiological agent was isolated and identified by the combined efforts of virologists in Marburg and Hamburg within the very short time of ...

Marburg Virus Disease

formation and transduction mechanisms are in dispute and remain to be investigated witlh renewed vigor. Lysogenic conversion may be operative in the myco-bacteria. Six of the papers are devoted to the study of lysogenic mycobacteria, whiclh exlhibit plhenotypic clhanges suclh as cell-wall alterations (expressed as chaniges in eitlher cell or colony morplhology), altered enzymatic activity, and ...

Marburg Virus Reverse Genetics Systems

The highly pathogenic Marburg virus (MARV) is a member of the Filoviridae family and belongs to the group of nonsegmented negative-strand RNA viruses. Reverse genetics systems established for MARV have been used to study various aspects of the viral replication cycle, analyze host responses, image viral infection, and screen for antivirals. This article provides an overview of the currently est...

Postexposure Treatment of Marburg Virus Infection

Rhesus monkeys are protected from disease when a recombinant vesicular stomatitis virus-based vaccine is administered 20-30 min after infection with Marburg virus. We protected 5/6 monkeys when this vaccine was given 24 h after challenge; 2/6 animals were protected when the vaccine was administered 48 h postinfection.